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CS-W001157 4
Total: USD 88.00

5-(Hydroxymethyl)pyrimidine

  • CAS No. 25193-95-7

  • Cat. No. CS-D0994
  • Purity≥98%
  • MDL No.MFCD03789623

*For research and further manufacturing use only, not for direct human use.

5-(Hydroxymethyl)pyrimidine|CS-D0994

Structure of 25193-95-7

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General Information

  • CAS No. 25193-95-7
  • Cat. No. CS-D0994
  • Purity ≥98%
  • MDL No. MFCD03789623
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O
  • Molecular Weight 110.11
  • Synonym(s) Pyrimidin-5-ylmethanol; 5-Pyrimidine methanol
  • SMILES OCC1=CN=CN=C1

Description

5-(Hydroxymethyl)pyrimidine features a pyrimidine core functionalized with a hydroxymethyl group, enabling direct incorporation into nucleoside analogs and bioactive heterocycles. This bench-stable derivative facilitates efficient derivatization under mild conditions, serving as a key scaffold in medicinal chemistry and agrochemical research.

Application

5-(Hydroxymethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient functionalization at the pyrimidine C5 position. Its hydroxymethyl group facilitates oxidation to carboxylic acid, reductive amination, or etherification, supporting diverse downstream modifications. The compound exhibits good bench stability and is compatible with standard coupling and protection protocols, making it suitable for modular synthesis of heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1

    References

    • GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang Patent: WO2013/130935 A1, 2013 ; Location in patent: Paragraph 0218 ;
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   -0.0311
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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