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CS-W001157 4
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2-Methyl-5-pyrimidinemethanol

  • CAS No. 2239-83-0

  • Cat. No. CS-W019609
  • Purity≥98%
  • MDL No.MFCD09414732

*For research and further manufacturing use only, not for direct human use.

2-Methyl-5-pyrimidinemethanol|CS-W019609

Structure of 2239-83-0

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General Information

  • CAS No. 2239-83-0
  • Cat. No. CS-W019609
  • Purity ≥98%
  • MDL No. MFCD09414732
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight None
  • Synonym(s) (2-Methylpyrimidin-5-yl)methanol; 5-Pyrimidinemethanol, 2-methyl- (7CI,8CI,9CI)
  • SMILES OCC1=CN=C(C)N=C1

Description

2-Methyl-5-pyrimidinemethanol features a pyrimidine core functionalized with a methyl group at C2 and a hydroxymethyl substituent at C5, delivering enhanced solubility and stability. This scaffold integrates readily into heterocyclic libraries, serving as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and nucleoside analogs.

Application

2-Methyl-5-pyrimidinemethanol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds through standard functional group transformations. Its bench-stable nature and compatibility with common coupling reactions facilitate straightforward derivatization. The molecule functions effectively as a synthetic intermediate for heterocyclic compounds, particularly in the development of kinase inhibitors and nucleoside analogs.

Synthesis

  • Route1

    References

    • US2014/107340 A1, ; Paragraph 0121 ;
  • Route2
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      126504-91-4
    • ~%
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      126504-92-5
    • In-stock
      2-Methyl-5-pyrimidinemethanol|CS-W019609
      2239-83-0

    References

    • Chemische Berichte, , vol. 123, # 9 p. 1885 - 1889

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P234-P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P312-P332+P313-P362+P364-P390-P403+P233-P405-P406-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   0.27732
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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