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CS-W001157 4
Total: USD 88.00

2-Chloro-6-fluorobenzoic acid

  • CAS No. 434-75-3

  • Cat. No. CS-W017484
  • Purity≥98%
  • MDL No.MFCD00002417

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-fluorobenzoic acid|CS-W017484

Structure of 434-75-3

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General Information

  • CAS No. 434-75-3
  • Cat. No. CS-W017484
  • Purity ≥98%
  • MDL No. MFCD00002417
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClFO₂
  • Molecular Weight None
  • Synonym(s) 2-chloro-6-fluorobenzoate
  • SMILES C1=C(C(=C(C=C1)Cl)C(O)=O)F

Description

Azo biotin-azide is a linker that contains a biotin moiety connected to an azide group through a spacer arm containing a diazo group that can be cleaved with 50 mM sodium dithionite solution. The biotin can be captured by streptavidin and the azide can react with terminal or strained alkynes.Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Application

2-Chloro-6-fluorobenzoic acid serves as a valuable building block for pharmaceutical and agrochemical synthesis, offering orthogonal halogen reactivity for subsequent cross-coupling or nucleophilic substitution. Its bench-stable carboxylic acid functionality enables direct derivatization into amides, esters, or acyl chlorides, while the meta-chloro and para-fluoro substituents provide predictable electronic effects and compatibility with standard coupling protocols in medicinal chemistry workflows.

Synthesis

  • Route1
    • 2-Chloro-6-fluorobenzaldehyde oxime|CS-W017543
      443-33-4
    • ~99%
    • In-stock
      2-Chloro-6-fluorobenzoic acid|CS-W017484
      434-75-3

    References

    • Giurg; Said; Syper; Mlochowski Synthetic Communications, 2001 , vol. 31, # 20 p. 3151 - 3159
  • Route2

    References

    • Choi, Joong-Kwon; Chang, Young-Kil; Hong, Sung Yeap Tetrahedron Letters, 1988 , vol. 29, # 16 p. 1967 - 1970
  • Route3

    References

    • Lock Chemische Berichte, 1936 , vol. 69, p. 2253,2255

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.1773
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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