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CS-W001157 4
Total: USD 88.00

4-Methoxyaniline hydrochloride

  • CAS No. 20265-97-8

  • Cat. No. CS-0150380
  • Purity≥98%
  • MDL No.MFCD00036388

*For research and further manufacturing use only, not for direct human use.

4-Methoxyaniline hydrochloride|CS-0150380

Structure of 20265-97-8

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General Information

  • CAS No. 20265-97-8
  • Cat. No. CS-0150380
  • Purity ≥98%
  • MDL No. MFCD00036388
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀ClNO
  • Molecular Weight 159.61
  • Synonym(s) p-Anisidine hydrochloride
  • SMILES COC1=CC=C(C=C1)N.Cl

Description

4-Methoxyaniline hydrochloride delivers a bench-stable, moisture-tolerant source of the para-methoxyaniline moiety. This salt form enhances solubility in aqueous and polar organic media, enabling seamless integration into synthetic workflows. It serves as a key intermediate for pharmaceuticals, agrochemicals, and functional dyes, where its electron-rich aromatic amine functionality supports efficient coupling reactions.

Application

4-Methoxyaniline hydrochloride serves as a stable, bench-ready amine source for nucleophilic aromatic substitution and coupling reactions. Its ortho- and para-directing methoxy group enables selective functionalization in heterocycle synthesis, while the hydrochloride salt enhances solubility and simplifies purification. Widely used in pharmaceutical intermediates and dye chemistry, it facilitates efficient amide formation and Ullmann-type couplings under standard conditions.

Synthesis

  • Route1
    • null|null
      100-17-4
    • ~70%
    • In-stock
      4-Methoxyaniline hydrochloride|CS-0150380
      20265-97-8

    References

    • Tetrahedron, , vol. 67, # 10 p. 1971 - 1976
  • Route2
    • null|null
      22700-44-3
    • ~99%
    • In-stock
      4-Methoxyaniline hydrochloride|CS-0150380
      20265-97-8

    References

    • Synthetic Communications, , vol. 28, # 3 p. 471 - 474
  • Route3
    • null|null
      104-94-9
    • ~%
    • In-stock
      4-Methoxyaniline hydrochloride|CS-0150380
      20265-97-8

    References

    • Molecules, , vol. 14, # 11 p. 4406 - 4413

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H317-H319-H334-H335
Precautionary Statements : P261-P264-P270-P271-P272-P280-P285-P305+P351+P338-P362-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.6992
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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