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CS-W001157 4
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3-Methoxyaniline hydrochloride

  • CAS No. 27191-09-9

  • Cat. No. CS-0450405
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Methoxyaniline hydrochloride|CS-0450405

Structure of 27191-09-9

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General Information

  • CAS No. 27191-09-9
  • Cat. No. CS-0450405
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀ClNO
  • Molecular Weight 159.61
  • Synonym(s) None
  • SMILES COC1=CC=CC(=C1)N.Cl

Description

3-Methoxyaniline hydrochloride is a bench-stable, moisture-tolerant derivative of aniline featuring a para-methoxy group that enhances electron density at the aromatic ring. This compound integrates readily into synthetic pathways requiring amine functionality with improved solubility and handling over free base analogs.

Application

3-Methoxyaniline hydrochloride serves as a stable, bench-ready building block for the synthesis of pharmaceutical intermediates and functionalized heterocycles. Its aniline functionality enables direct coupling reactions, while the methoxy group provides moderate electron-donating character and orthogonal reactivity. The hydrochloride salt enhances solubility and handling, facilitating purification and compatibility with standard amine protection strategies in multi-step syntheses.

Synthesis

  • Route1
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    • ~%
    • In-stock
      3-Methoxyaniline hydrochloride|CS-0450405
      27191-09-9

    References

    • Kitamura, Mitsuru; Suga, Takahiro; Chiba, Shunsuke; Narasaka, Koichi Organic Letters, 2004 , vol. 6, # 24 p. 4619 - 4621

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.6992
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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