Lot numbers can be found on the outside label of a product:
tert-Butyl (4-methoxyphenyl)carbamate
-
CAS No. 18437-68-8
- Cat. No. CS-0038620
- Purity≥98%
- MDL No.MFCD00816766
*For research and further manufacturing use only, not for direct human use.
Structure of 18437-68-8
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 18437-68-8
- Cat. No. CS-0038620
- Purity ≥98%
- MDL No. MFCD00816766
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₁₇NO₃
- Molecular Weight 223.27
- Synonym(s) TERT-BUTYL-4-METHOXYCARBANILATE
- SMILES CC(C)(C)OC(=O)NC1=CC=C(C=C1)OC
Description
tert-Butyl (4-methoxyphenyl)carbamate serves as a robust protecting group for primary amines, offering enhanced stability under acidic conditions. The para-methoxy substituent imparts electron-donating character, improving compatibility with diverse reaction sequences. This derivative facilitates selective deprotection in mild conditions, enabling efficient synthesis of functionalized arylamines.
Application
tert-Butyl (4-methoxyphenyl)carbamate serves as a stable, bench-ready amino protecting group for primary amines, enabling efficient N-alkylation and coupling reactions. Its orthogonality to standard deprotection conditions facilitates sequential functionalization in complex molecule synthesis. The 4-methoxyphenyl moiety enhances solubility and simplifies purification via chromatography, while the tert-butyl carbamate fragment is readily removed under mild acidic conditions, making it ideal for peptide and medicinal chemistry applications.
Synthesis
-
Route1
-
In-stock
24424-99-5 -
104-94-9 - ~99%
-
In-stock
18437-68-8
References
-
Sunitha, Sadula; Kanjilal, Sanjit; Reddy, P. Srinivasa; Prasad, Rachapudi B.N. Tetrahedron Letters, 2008 , vol. 49, # 16 p. 2527 - 2532
-
-
Route2
-
104-92-7
-
In-stock
4248-19-5 - ~99%
-
In-stock
18437-68-8
References
-
Isley, Nicholas A.; Dobarco, Sebastian; Lipshutz, Bruce H. Green Chemistry, 2014 , vol. 16, # 3 p. 1480 - 1488
-
-
Route3
-
1111249-38-7
- ~94%
-
In-stock
18437-68-8
References
-
Ankner, Tobias; Hilmersson, Goeran Organic Letters, 2009 , vol. 11, # 3 p. 503 - 506
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 47.56
- LogP 3.0422
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 2
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- tert-Butyl (4-methoxyphenyl)carbamate sigmatert-Butyl (4-methoxyphenyl)carbamate manufacturertert-Butyl (4-methoxyphenyl)carbamate pricetert-Butyl (4-methoxyphenyl)carbamate structuretert-Butyl (4-methoxyphenyl)carbamate SDSbuy tert-Butyl (4-methoxyphenyl)carbamatetert-Butyl (4-methoxyphenyl)carbamate suppliertert-Butyl (4-methoxyphenyl)carbamate usestert-Butyl (4-methoxyphenyl)carbamate molecular weightprice of tert-Butyl (4-methoxyphenyl)carbamatetert-Butyl (4-methoxyphenyl)carbamate chemical name formula of tert-Butyl (4-methoxyphenyl)carbamate