2'-Deoxy-2'-fluoroarabinoadenosine

Name: 2'-Deoxy-2'-fluoroarabinoadenosine
Brand: ChemScene
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CAS No. 20227-41-2
Cat. No. CS-0513841
Purity≥98%
MDL No.MFCD12911815

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2'-Deoxy-2'-fluoroarabinoadenosine|CS-0513841

Structure of 20227-41-2

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Description

2'-Deoxy-2'-fluoroarabinoadenosine is a fluorinated nucleoside analog featuring a 2'-fluoro substitution in the arabinose sugar configuration. This modification enhances metabolic stability and resistance to enzymatic degradation, enabling prolonged intracellular retention. The compound integrates efficiently into RNA during synthesis, acting as a potent chain terminator with applications in antiviral research and targeted nucleic acid labeling.

Application

2'-Deoxy-2'-fluoroarabinoadenosine serves as a valuable nucleoside analog in antiviral and anticancer research, featuring a 2'-fluoro substitution that enhances metabolic stability and resistance to enzymatic degradation. The arabinose configuration imparts distinct conformational rigidity, enabling selective incorporation into oligonucleotides and facilitating studies in RNA-directed therapeutics. Its bench-stable solid form and compatibility with standard coupling protocols make it a practical building block for synthetic oligonucleotide workflows.

General Information

CAS No. 20227-41-2
Cat. No. CS-0513841
Purity ≥98%
MDL No. MFCD12911815
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₂FN₅O₃
Molecular Weight 269.23
Synonym(s) None
SMILES O[C@H]1[C@H](F)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1CO

Computational Chemistry Data

TPSA 119.31
LogP -1.0028
H_Acceptors 8
H_Donors 3
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Nucleosides & Nucleotides 2'-F-modified Nucleoside

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Key Words

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2'-Deoxy-2'-fluoroarabinoadenosine

CAS No. 20227-41-2

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