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CS-W001157 4
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5-Ethylpyridin-2-amine

  • CAS No. 19842-07-0

  • Cat. No. CS-0152497
  • Purity≥95%
  • MDL No.MFCD09757479

*For research and further manufacturing use only, not for direct human use.

5-Ethylpyridin-2-amine|CS-0152497

Structure of 19842-07-0

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General Information

  • CAS No. 19842-07-0
  • Cat. No. CS-0152497
  • Purity ≥95%
  • MDL No. MFCD09757479
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight 122.17
  • Synonym(s) 5-ETHYL-PYRIDIN-2-YLAMINE
  • SMILES NC1=NC=C(CC)C=C1

Description

5-Ethylpyridin-2-amine features a pyridine core functionalized with an ethyl group at the 5-position and a primary amine at the 2-position, delivering enhanced solubility and nucleophilicity. This scaffold integrates readily into transition metal catalysis and ligand design, offering robust coordination geometry and tunable electronic properties for synthetic applications.

Application

5-Ethylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-based scaffolds through standard coupling and functionalization reactions. Its ethyl substituent enhances lipophilicity and modulates electronic properties, while the ortho-amino group facilitates direct derivatization, cross-coupling, or cyclization. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • In-stock
      2-Amino-5-bromopyridine|CS-D1666
      1072-97-5
    • null|null
      557-20-0
    • ~99%
    • In-stock
      5-Ethylpyridin-2-amine|CS-0152497
      19842-07-0

    References

    • BIOLIPOX AB Patent: WO2007/51982 A1, 2007 ; Location in patent: Page/Page column 52 ;
  • Route2
    • 5-Vinylpyridin-2-amine|CS-0590743
      62114-80-1
    • ~%
    • In-stock
      5-Ethylpyridin-2-amine|CS-0152497
      19842-07-0

    References

    • WO2004/96810 A1, ; Page 174 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.2262
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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