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CS-W001157 4
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2-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

  • CAS No. 1375301-91-9

  • Cat. No. CS-W018913
  • Purity≥97%
  • MDL No.MFCD12032616

*For research and further manufacturing use only, not for direct human use.

2-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine|CS-W018913

Structure of 1375301-91-9

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General Information

  • CAS No. 1375301-91-9
  • Cat. No. CS-W018913
  • Purity ≥97%
  • MDL No. MFCD12032616
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₉BN₂O₂
  • Molecular Weight 246.11
  • Synonym(s) Pyrimidine,2-cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • SMILES CC1(C)C(C)(C)OB(C2=CN=C(C3CC3)N=C2)O1

Description

This boronate ester features a cyclopropyl-substituted pyrimidine core, enabling efficient cross-coupling under standard conditions. The tetramethyl-dioxaborolane moiety enhances stability and reactivity, while the cyclopropyl group imparts favorable steric and electronic properties for C–C bond formation in medicinal chemistry and materials synthesis.

Application

2-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine serves as a versatile Suzuki-Miyaura coupling partner, enabling efficient C–C bond formation under mild conditions. The boronate ester group exhibits excellent stability, tolerance to diverse functional groups, and compatibility with common reaction protocols. Its pyrimidine core provides a robust scaffold for constructing biologically relevant heterocycles and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   44.24
  • LogP   1.6532
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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