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CS-W001157 4
Total: USD 88.00

(4-Methoxy-2-methylphenyl)boronic acid

  • CAS No. 208399-66-0

  • Cat. No. CS-W002973
  • Purity≥95%
  • MDL No.MFCD02684315

*For research and further manufacturing use only, not for direct human use.

(4-Methoxy-2-methylphenyl)boronic acid|CS-W002973

Structure of 208399-66-0

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General Information

  • CAS No. 208399-66-0
  • Cat. No. CS-W002973
  • Purity ≥95%
  • MDL No. MFCD02684315
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁BO₃
  • Molecular Weight None
  • Synonym(s) 4-Methoxy-2-methylphenylboronic acid
  • SMILES CC1=CC(OC)=CC=C1B(O)O

Application

(4-Methoxy-2-methylphenyl)boronic acid serves as a reliable building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its stability in air and moisture facilitates handling and purification, while the methoxy and methyl groups provide predictable electronic and steric modulation. This reagent is well-suited for constructing substituted biaryls and heterocyclic scaffolds in medicinal chemistry and materials synthesis.

Synthesis

  • Route1

    References

    • Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A. Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
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      (4-Methoxy-2-methylphenyl)boronic acid|CS-W002973
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    References

    • Mello, Jesse V.; Finney, Nathaniel S. Organic Letters, 2001 , vol. 3, # 26 p. 4263 - 4265
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      (4-Methoxy-2-methylphenyl)boronic acid|CS-W002973
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    References

    • De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L. Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 787 - 797

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   -0.31658
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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