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CS-W001157 4
Total: USD 88.00

2,5-Dichloropyrazine

  • CAS No. 19745-07-4

  • Cat. No. CS-W004751
  • Purity≥97%
  • MDL No.MFCD04117886

*For research and further manufacturing use only, not for direct human use.

2,5-Dichloropyrazine|CS-W004751

Structure of 19745-07-4

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General Information

  • CAS No. 19745-07-4
  • Cat. No. CS-W004751
  • Purity ≥97%
  • MDL No. MFCD04117886
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂Cl₂N₂
  • Molecular Weight 148.98
  • Synonym(s) 2,5-Dichloroprazine
  • SMILES ClC1=CN=C(Cl)C=N1

Description

2,5-Dichloropyrazine serves as a pivotal heterocyclic scaffold in medicinal chemistry, offering a rigid, electron-deficient core that facilitates selective coupling reactions. This bench-stable compound integrates readily into kinase inhibitors and targeted therapeutics, where its chlorine substituents enable directional functionalization through palladium-catalyzed cross-coupling.

Application

2,5-Dichloropyrazine serves as a versatile heterocyclic building block in medicinal chemistry and agrochemical synthesis. Its dual chlorine substituents enable selective nucleophilic substitution reactions, facilitating the installation of diverse aryl, heteroaryl, and amino groups under mild conditions. The scaffold exhibits excellent bench stability and compatibility with standard coupling protocols, making it well-suited for iterative functionalization and modular library construction.

Synthesis

  • Route1

    References

    • WO2008/85316 A1, ; Page/Page column 53-54 ; WO 2008/085316 A1
  • Route2
    • null|null
      6863-76-9
    • ~35%
    • In-stock
      2,5-Dichloropyrazine|CS-W004751
      19745-07-4

    References

    • US2005/234046 A1, ; Page/Page column 70 ; US 20050234046 A1
  • Route3

    References

    • WO2008/46226 A1, ; Page/Page column 60 ; WO 2008/046226 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.7834
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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