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CS-W001157 4
Total: USD 88.00

5-Chloro-2-hydroxypyrazine

  • CAS No. 89180-45-0

  • Cat. No. CS-W019738
  • Purity≥98%
  • MDL No.MFCD11109884

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-hydroxypyrazine|CS-W019738

Structure of 89180-45-0

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General Information

  • CAS No. 89180-45-0
  • Cat. No. CS-W019738
  • Purity ≥98%
  • MDL No. MFCD11109884
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃ClN₂O
  • Molecular Weight 130.53
  • Synonym(s) 5-Chloro-2(1H)-pyrazinone; 5-Chloropyrazin-2-ol; 5-Chloropyrazin-2-ol, 5-Chloro-2-hydroxy-1,4-diazine
  • SMILES O=C1C=NC(Cl)=CN1

Description

5-Chloro-2-hydroxypyrazine features a reactive hydroxyl group flanked by a chlorine substituent, enabling selective functionalization in heterocyclic synthesis. This bench-stable scaffold integrates readily into bioactive molecule design, offering enhanced solubility and targeted reactivity for medicinal chemistry applications.

Application

5-Chloro-2-hydroxypyrazine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C2 position via nucleophilic substitution or transition-metal-catalyzed coupling. The hydroxyl group provides a handle for derivatization, while the chloropyrazine scaffold offers excellent stability and compatibility with standard synthetic protocols. Its well-defined reactivity profile facilitates efficient incorporation into heterocyclic APIs and advanced intermediates.

Synthesis

  • Route1

    References

    • EP1698626 A1, ; Page/Page column 28-29 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   0.4233
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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