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CS-W001157 4
Total: USD 88.00

(3S,4S)-4-Fluoropyrrolidin-3-ol hydrochloride

  • CAS No. 1909293-52-2

  • Cat. No. CS-0058680
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3S,4S)-4-Fluoropyrrolidin-3-ol hydrochloride|CS-0058680

Structure of 1909293-52-2

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General Information

  • CAS No. 1909293-52-2
  • Cat. No. CS-0058680
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉ClFNO
  • Molecular Weight 141.57
  • Synonym(s) (3S,4S)-4-FLUOROPYRROLIDIN-3-OL HCL
  • SMILES O[C@@H]1[C@@H](F)CNC1.Cl

Description

This chiral pyrrolidinol hydrochloride features a fluorinated ring system with defined stereochemistry at the 3- and 4-positions, delivering enhanced metabolic stability and improved membrane permeability. The protonated amine enhances aqueous solubility while preserving favorable pharmacokinetic properties. Designed for medicinal chemistry applications, this scaffold integrates readily into bioactive molecules requiring controlled polarity and conformational rigidity.

Application

(3S,4S)-4-Fluoropyrrolidin-3-ol hydrochloride serves as a stereochemically defined building block for bioactive heterocycles, enabling direct incorporation into medicinal chemistry libraries. Its fluorinated pyrrolidine core exhibits enhanced metabolic stability and modulates target binding affinity through stereoselective interactions. The hydrochloride salt form ensures excellent bench stability, solubility, and ease of handling in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   -0.2896
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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