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CS-W001157 4
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trans-4-Fluoropyrrolidin-3-ol hydrochloride

  • CAS No. 2006333-41-9

  • Cat. No. CS-0042168
  • Molecule weight141.57
  • Purity≥97%
  • MDL No.MFCD23105899

*For research and further manufacturing use only, not for direct human use.

trans-4-Fluoropyrrolidin-3-ol hydrochloride|CS-0042168

Structure of 2006333-41-9

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General Information

  • CAS No. 2006333-41-9
  • Cat. No. CS-0042168
  • Purity ≥97%
  • MDL No. MFCD23105899
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉ClFNO
  • Molecular Weight 141.57
  • Synonym(s) (3R,4R)-4-fluoropyrrolidin-3-ol hydrochloride
  • SMILES O[C@H]1CNC[C@@H]1F.Cl

Description

trans-4-Fluoropyrrolidin-3-ol hydrochloride features a conformationally constrained pyrrolidine ring with a fluorine atom at the 4-position, imparting enhanced metabolic stability and improved membrane permeability. This bench-stable, moisture-tolerant compound integrates readily into bioactive molecule scaffolds for medicinal chemistry applications.

Application

trans-4-Fluoropyrrolidin-3-ol hydrochloride serves as a key chiral building block in medicinal chemistry, enabling the synthesis of fluorinated pyrrolidine scaffolds prevalent in bioactive molecules. Its bench-stable hydrochloride salt form facilitates handling and purification, while the trans stereochemistry ensures predictable conformational behavior in downstream transformations. The molecule exhibits robust functional group tolerance and functions effectively in amide coupling, nucleophilic substitution, and cyclization reactions critical to API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   -0.2896
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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