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CS-W001157 4
Total: USD 88.00

3,5-Dimethylphenylboronic acid

  • CAS No. 172975-69-8

  • Cat. No. CS-D1028
  • Purity≥97%
  • MDL No.MFCD00185689

*For research and further manufacturing use only, not for direct human use.

3,5-Dimethylphenylboronic acid|CS-D1028

Structure of 172975-69-8

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General Information

  • CAS No. 172975-69-8
  • Cat. No. CS-D1028
  • Purity ≥97%
  • MDL No. MFCD00185689
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁BO₂
  • Molecular Weight 149.98
  • Synonym(s) m-Xylene-5-boronic Acid (contains varying amounts of Anhydride); 3,5-Dimethylphenylboronic acid
  • SMILES CC1=CC(C)=CC(B(O)O)=C1

Description

Fmoc-Gly-Gly-L-Phe is a cleavable ADC linker with an Fmoc group and a terminal carboxylic acid group. The Fmoc group can be deprotected under basic conditions to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. Reagent grade, for research use only.

Synthesis

  • Route1

    References

    • Chemical Communications, , # 25 p. 3213 - 3214
  • Route2
    • null|null
      121-43-7
    • In-stock
      1-Bromo-3,5-dimethylbenzene|CS-W016968
      556-96-7
    • ~84%
    • In-stock
      3,5-Dimethylphenylboronic acid|CS-D1028
      172975-69-8

    References

    • Schmid, Markus; Eberhardt, Robert; Klinga, Martti; Leskelae, Markku; Rieger, Bernhard Organometallics, 2001 , vol. 20, # 11 p. 2321 - 2330
  • Route3
    • null|null
      5419-55-6
    • In-stock
      1-Bromo-3,5-dimethylbenzene|CS-W016968
      556-96-7
    • ~29%
    • In-stock
      3,5-Dimethylphenylboronic acid|CS-D1028
      172975-69-8

    References

    • University of Pittsburgh Patent: US5834434 A1, 1998 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   -0.01676
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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