3-Amino-2,2-dimethylpropanoic acid

Name: 3-Amino-2,2-dimethylpropanoic acid
Brand: ChemScene
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CAS No. 19036-43-2
Cat. No. CS-0107300
Purity≥95%
MDL No.MFCD09055365

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Amino-2,2-dimethylpropanoic acid|CS-0107300

Structure of 19036-43-2

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General Information

CAS No. 19036-43-2
Cat. No. CS-0107300
Purity ≥95%
MDL No. MFCD09055365
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₁NO₂
Molecular Weight 117.15
Synonym(s) 3-AMINO-2,2-DIMETHYL-PROPANOIC ACID
SMILES O=C(O)C(C)(C)CN

Description

3-Amino-2,2-dimethylpropanoic acid features a sterically hindered α-amino acid scaffold with a tertiary carbon adjacent to the carboxyl group. This structural motif enhances metabolic stability and facilitates incorporation into peptide sequences without racemization. The molecule bears a primary amine and a protected β-carbon framework, enabling use in solid-phase synthesis and bioconjugation workflows.

Application

3-Amino-2,2-dimethylpropanoic acid serves as a valuable building block in peptide synthesis and medicinal chemistry, offering a sterically hindered α-amino acid scaffold with enhanced metabolic stability. Its tertiary β-carbon prevents racemization during coupling, enabling reliable peptide chain elongation. The molecule's dual functionality—amine and carboxylic acid—facilitates straightforward conjugation and derivatization, while its bench-stable crystalline form simplifies handling and purification.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P501

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Computational Chemistry Data

TPSA 63.32
LogP 0.0559
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

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3-Amino-2,2-dimethylpropanoic acid

CAS No. 19036-43-2

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