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CS-W001157 4
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Ethyl 3-amino-2,2-dimethylpropanoate hydrochloride

  • CAS No. 80253-38-9

  • Cat. No. CS-0035428
  • Purity≥97%
  • MDL No.MFCD00102231

*For research and further manufacturing use only, not for direct human use.

Ethyl 3-amino-2,2-dimethylpropanoate hydrochloride|CS-0035428

Structure of 80253-38-9

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General Information

  • CAS No. 80253-38-9
  • Cat. No. CS-0035428
  • Purity ≥97%
  • MDL No. MFCD00102231
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆ClNO₂
  • Molecular Weight 181.66
  • Synonym(s) 3-AMINO-2,2-DIMETHYL-PROPIONIC ACID ETHYL ESTER HYDROCHLORIDE
  • SMILES O=C(OCC)C(C)(C)CN.[H]Cl

Description

Ethyl 3-amino-2,2-dimethylpropanoate hydrochloride features a sterically hindered quaternary carbon center paired with a protonated primary amine, enabling robust salt formation. This bench-stable derivative delivers enhanced solubility in polar solvents while maintaining compatibility with amine-directed transformations. The ethyl ester moiety supports facile downstream derivatization in synthetic sequences.

Application

Ethyl 3-amino-2,2-dimethylpropanoate hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of sterically hindered amino acid analogs and heterocyclic scaffolds. Its tertiary α-carbon enhances stability and reduces racemization risk during peptide coupling. The amine functionality readily participates in acylation, alkylation, and reductive amination reactions, while the ethyl ester permits selective hydrolysis or transformation under mild conditions. This compound facilitates efficient access to complex molecular architectures with minimal purification challenges.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.9562
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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