Lot numbers can be found on the outside label of a product:
Pleuromutilin
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CAS No. 125-65-5
- Cat. No. CS-5813
- Purity≥98%
- MDL No.MFCD01939630
*For research and further manufacturing use only, not for direct human use.
Structure of 125-65-5
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General Information
- CAS No. 125-65-5
- Cat. No. CS-5813
- Purity ≥98%
- MDL No. MFCD01939630
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₂₂H₃₄O₅
- Molecular Weight 378.50
- Synonym(s) Drosophilin B; Mutilin 14-glycolate
- SMILES C[C@@H]([C@@H]([C@@](C)(C[C@H]1OC(CO)=O)C=C)O)C(CC[C@H]2C)(CCC3=O)[C@]3([H])C21C
Description
A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 M in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 M, but at higher concentration (~100 M) it reversibly reduces K+ currents.
Application
Pleuromutilin serves as a privileged scaffold in medicinal chemistry, offering a rigid tetracyclic core with defined stereochemistry that enables selective functionalization at C14 and C2 positions. Its structural stability and low metabolic liability make it a valuable building block for antibacterial and antiviral lead optimization. The molecule facilitates direct derivatization via nucleophilic substitution or transition-metal-catalyzed coupling, supporting efficient synthesis of complex analogs with enhanced pharmacokinetic profiles.
Synthesis
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Route1
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80878-40-6 - ~%
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In-stock
125-65-5
References
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Journal of the American Chemical Society, , vol. 111, # 21 p. 8284 - 8286
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Route2
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80878-41-7
- ~%
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In-stock
125-65-5
References
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Journal of the American Chemical Society, , vol. 111, # 21 p. 8284 - 8286
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Route3
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80878-39-3
- ~%
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In-stock
125-65-5
References
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Journal of the American Chemical Society, , vol. 111, # 21 p. 8284 - 8286
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07,GHS09
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Signal Word : Warning
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H410
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Precautionary Statements : P264-P270-P273-P330-P391-P501
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Quality Control
Computational Chemistry Data
- TPSA 83.83
- LogP 2.8852
- H_Acceptors 5
- H_Donors 2
- Rotatable_Bonds 3
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Key Words
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