NH2-PEG3-C1-Boc

Name: NH2-PEG3-C1-Boc
Brand: ChemScene
Availability: InStock
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CAS No. 189808-70-6
Cat. No. CS-0100052
Purity≥98%
MDL No.MFCD30730374

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 189808-70-6
Cat. No. CS-0100052
Purity ≥98%
MDL No. MFCD30730374
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₅NO₅
Molecular Weight 263.33
Synonym(s) PROTAC Linker 5
SMILES NCCOCCOCCOCC(OC(C)(C)C)=O

Description

NH2-PEG3-C1-Boc features a terminal amine linked via a three-ethylene glycol unit to a C1 spacer bearing a Boc protecting group. This bifunctional construct enables selective conjugation and orthogonal protection in peptide synthesis, offering enhanced solubility and stability under standard bench conditions.

Application

NH₂-PEG₃-C₁-Boc serves as a versatile bifunctional building block for peptide and conjugate synthesis, combining the solubility and stability of a triethylene glycol spacer with a protected amine (Boc) and a reactive terminal amine. The PEG₃ chain enhances aqueous solubility and reduces aggregation, while the Boc group enables orthogonal deprotection under mild acidic conditions. This compound facilitates efficient coupling reactions in solid-phase and solution-phase workflows, offering reliable handling and clean purification—ideal for constructing complex biomolecules and targeted delivery systems.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 80.01
LogP 0.3366
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 10

Other Classifications

Life Science PROTAC PROTAC Linker

Life Science Linker Amino PEG

Building Blocks Skeleton Fatty chain compounds

Building Blocks Functional Group PEG

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

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NH2-PEG3-C1-Boc

CAS No. 189808-70-6

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