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CS-W001157 4
Total: USD 88.00

Tris(3,5-di-tert-butylphenyl)phosphine

  • CAS No. 189756-42-1

  • Cat. No. CS-0527414
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Tris(3,5-di-tert-butylphenyl)phosphine|CS-0527414

Structure of 189756-42-1

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General Information

  • CAS No. 189756-42-1
  • Cat. No. CS-0527414
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₂H₆₃P
  • Molecular Weight 598.92
  • Synonym(s) Tris(3,5-di-tert-butylphenyl)phosphane
  • SMILES CC(C1=CC(C(C)(C)C)=CC(P(C2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2)C3=CC(C(C)(C)C)=CC(C(C)(C)C)=C3)=C1)(C)C

Description

Tris(3,5-di-tert-butylphenyl)phosphine features a sterically shielded phosphorus center flanked by three bulky 3,5-di-tert-butylphenyl groups, conferring exceptional stability and resistance to oxidation. This bench-stable ligand enables reliable coordination in palladium-catalyzed cross-coupling reactions under ambient conditions.

Application

Tris(3,5-di-tert-butylphenyl)phosphine serves as a sterically shielded, bench-stable phosphine ligand that enables efficient cross-coupling reactions under mild conditions. Its bulky substituents enhance oxidative stability and promote rapid reductive elimination in palladium-catalyzed transformations. The ligand exhibits broad functional group tolerance and facilitates catalyst turnover in Suzuki, Stille, and Negishi couplings, making it a reliable choice for complex molecule synthesis and process-scale applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   0
  • LogP   11.2298
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   3

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