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Structure of 1886967-25-4
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This bicyclic amine hydrochloride features a rigid, strained [1.1.1]bicyclo[1.1.1]pentane scaffold bearing a chlorine substituent and a protonated amine group. The structure imparts exceptional stability and enhanced lipophilicity, enabling efficient membrane permeation. This compound serves as a valuable building block in medicinal chemistry for bioisosteric replacement of traditional alkyl or aryl groups, particularly in optimizing metabolic stability and solubility profiles within drug candidates.
3-Chlorobicyclo[1.1.1]pentan-1-amine hydrochloride serves as a rigid, sterically constrained building block for medicinal chemistry and target-oriented synthesis. Its bicyclic scaffold imparts conformational rigidity, while the primary amine functionality enables straightforward derivatization via amidation, alkylation, or reductive amination. The chloride salt enhances solubility and stability, facilitating handling and purification in standard laboratory workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: