tert-Butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Name: tert-Butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
Brand: ChemScene
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CAS No. 1160246-91-2
Cat. No. CS-D0631
Purity≥98%
MDL No.MFCD12198529

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tert-Butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate|CS-D0631

Structure of 1160246-91-2

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General Information

CAS No. 1160246-91-2
Cat. No. CS-D0631
Purity ≥98%
MDL No. MFCD12198529
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₄N₂O₃
Molecular Weight 256.34
Synonym(s) 8-Boc-3-aMino-1-oxa-8-azaspiro[4.5]decane
SMILES O=C(OC(C)(C)C)N1CCC2(OCC(N)C2)CC1

Description

tert-Butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate is a spirocyclic heterobicyclic scaffold featuring a pendant amino group and a bench-stable tert-butyl ester. This configuration enables direct incorporation into complex molecular architectures, particularly in medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors. The rigid, three-dimensional framework enhances metabolic stability and modulates solubility profiles during lead optimization.

Application

tert-Butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry, enabling efficient access to complex heterocycles through standard amine functionalization and coupling reactions. The protected amine and ester groups offer excellent bench stability, orthogonal reactivity, and compatibility with diverse synthetic transformations. Its rigid spiro architecture supports conformational constraint in target molecules, enhancing binding affinity and metabolic stability in lead optimization campaigns.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 64.79
LogP 1.5037
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

CAS No. 1160246-91-2

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