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CS-W001157 4
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2-Aminomethyl-5-methoxypyridine

  • CAS No. 905306-69-6

  • Cat. No. CS-0084610
  • Purity≥97%
  • MDL No.MFCD10697534

*For research and further manufacturing use only, not for direct human use.

2-Aminomethyl-5-methoxypyridine|CS-0084610

Structure of 905306-69-6

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General Information

  • CAS No. 905306-69-6
  • Cat. No. CS-0084610
  • Purity ≥97%
  • MDL No. MFCD10697534
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) (5-Methoxypyridin-2-yl)methanamine
  • SMILES COC1=CN=C(CN)C=C1

Description

2-Aminomethyl-5-methoxypyridine features a pyridine core functionalized with a methoxy group at the 5-position and a primary amine-bearing methyl linker at the 2-position. This configuration enables direct integration into bioactive scaffolds, offering enhanced solubility and metabolic stability in medicinal chemistry applications. The pendant amine facilitates conjugation or salt formation for improved formulation properties.

Application

2-Aminomethyl-5-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through standard functional group transformations. Its amine and methoxy groups offer orthogonal reactivity, facilitating derivatization via alkylation, acylation, or coupling reactions. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • He, Gang; Zhang, Shu-Yu; Nack, William A.; Li, Qiong; Chen, Gong Angewandte Chemie - International Edition, 2013 , vol. 52, # 42 p. 11124 - 11128 Angew. Chem., 2013 , vol. 125, # 42 p. 11330 - 11334,5
  • Route2

    References

    • He, Gang; Zhang, Shu-Yu; Nack, William A.; Li, Qiong; Chen, Gong Angewandte Chemie - International Edition, 2013 , vol. 52, # 42 p. 11124 - 11128 Angew. Chem., 2013 , vol. 125, # 42 p. 11330 - 11334,5

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.5489
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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