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CS-W001157 4
Total: USD 88.00

H-D-Tyr(tBu)-OH

  • CAS No. 186698-58-8

  • Cat. No. CS-0041673
  • Purity≥98%
  • MDL No.MFCD00077112

*For research and further manufacturing use only, not for direct human use.

H-D-Tyr(tBu)-OH|CS-0041673

Structure of 186698-58-8

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General Information

  • CAS No. 186698-58-8
  • Cat. No. CS-0041673
  • Purity ≥98%
  • MDL No. MFCD00077112
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₉NO₃
  • Molecular Weight 237.29
  • Synonym(s) None
  • SMILES O=C(O)[C@H](N)CC1=CC=C(OC(C)(C)C)C=C1

Description

H-D-Tyr(tBu)-OH is a bench-stable, moisture-tolerant D-amino acid derivative featuring a tert-butyl-protected phenolic hydroxyl group. This configuration enables selective incorporation into peptide sequences where metabolic stability and resistance to enzymatic degradation are critical. The protected tyrosine side chain simplifies purification and enhances compatibility with standard solid-phase synthesis protocols.

Application

H-D-Tyr(tBu)-OH serves as a stable, bench-ready building block for the synthesis of D-peptide analogs and bioactive oligomers. The tert-butyl-protected tyrosine side chain enables orthogonal functionalization and facilitates purification, while the D-configured backbone supports conformational studies and metabolic stability in peptidomimetic design. This derivative reacts efficiently in standard amide coupling protocols and functions reliably in solid-phase and solution-phase peptide synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   1.8183
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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