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CS-W001157 4
Total: USD 88.00

H-D-SER(TBU)-OH

  • CAS No. 18783-53-4

  • Cat. No. CS-0043573
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD00077107

*For research and further manufacturing use only, not for direct human use.

H-D-SER(TBU)-OH|CS-0043573

Structure of 18783-53-4

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General Information

  • CAS No. 18783-53-4
  • Cat. No. CS-0043573
  • Purity ≥97%
  • MDL No. MFCD00077107
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES N[C@H](COC(C)(C)C)C(O)=O

Description

H-D-SER(TBU)-OH is a bench-stable, moisture-tolerant serine derivative featuring a tert-butyl ester-protected hydroxyl group. This protected functionality enables straightforward incorporation into peptide synthesis workflows, offering enhanced solubility and compatibility with standard coupling conditions.

Application

H-D-SER(TBU)-OH serves as a stable, bench-ready building block for the synthesis of D-serine-containing peptides and peptidomimetics. The tert-butyl ester group provides excellent stability and orthogonal protection, enabling straightforward deprotection under mild acidic conditions. Its compatibility with standard coupling protocols and functional group tolerance facilitates efficient incorporation into complex peptide scaffolds.

Synthesis

  • Route1

    References

    • Journal of Organic Chemistry, , vol. 54, # 19 p. 4529 - 4535

Safety Information

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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   0.2134
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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