O-(tert-Butyl)-L-serine

Name: O-(tert-Butyl)-L-serine
Brand: ChemScene
Availability: InStock
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CAS No. 18822-58-7
Cat. No. CS-W010872
Purity≥97%
MDL No.MFCD00066088

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

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Description

O-(tert-Butyl)-L-serine features a sterically hindered tert-butyl group that enhances stability and reduces side reactions. This protected serine derivative integrates readily into peptide synthesis workflows, offering reliable coupling efficiency and improved solubility under standard conditions.

Application

O-(tert-Butyl)-L-serine serves as a robust, bench-stable building block for peptide synthesis, enabling site-specific incorporation of serine derivatives with enhanced solubility and reduced side-chain reactivity. Its tert-butyl ether protection offers orthogonal stability during standard coupling conditions and facilitates selective deprotection under mild acidic conditions, simplifying purification and improving yield in complex sequence assembly.

General Information

CAS No. 18822-58-7
Cat. No. CS-W010872
Purity ≥97%
MDL No. MFCD00066088
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₅NO₃
Molecular Weight 161.20
Synonym(s) None
SMILES N[C@@H](COC(C)(C)C)C(O)=O

Computational Chemistry Data

TPSA 72.55
LogP 0.2134
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Serine and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids Side Chain Protected Amino Acids (N,C-termini Free)

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O-(tert-Butyl)-L-serine

CAS No. 18822-58-7

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