Lot numbers can be found on the outside label of a product:
O-(tert-Butyl)-L-serine
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CAS No. 18822-58-7
- Cat. No. CS-W010872
- Purity≥97%
- MDL No.MFCD00066088
*For research and further manufacturing use only, not for direct human use.
Structure of 18822-58-7
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General Information
- CAS No. 18822-58-7
- Cat. No. CS-W010872
- Purity ≥97%
- MDL No. MFCD00066088
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₁₅NO₃
- Molecular Weight 161.20
- Synonym(s) None
- SMILES N[C@@H](COC(C)(C)C)C(O)=O
Description
O-(tert-Butyl)-L-serine features a sterically hindered tert-butyl group that enhances stability and reduces side reactions. This protected serine derivative integrates readily into peptide synthesis workflows, offering reliable coupling efficiency and improved solubility under standard conditions.
Application
O-(tert-Butyl)-L-serine serves as a robust, bench-stable building block for peptide synthesis, enabling site-specific incorporation of serine derivatives with enhanced solubility and reduced side-chain reactivity. Its tert-butyl ether protection offers orthogonal stability during standard coupling conditions and facilitates selective deprotection under mild acidic conditions, simplifying purification and improving yield in complex sequence assembly.
Synthesis
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Route1
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In-stock
1676-75-1 - ~%
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In-stock
18822-58-7
References
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Justus Liebigs Annalen der Chemie, , vol. 670, p. 127 - 136
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Route2
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In-stock
1872-59-9 - ~%
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In-stock
18822-58-7
References
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Journal of the American Chemical Society, , vol. 85, p. 201 - 207
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Route3
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20700-93-0 - ~99%
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In-stock
18822-58-7
References
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Nakajima, Kiichiro; Neya, Masahiro; Yamada, Shinichi; Okawa, Kenji Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 9 p. 3049 - 3050
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 72.55
- LogP 0.2134
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 3
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Key Words
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