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CS-W001157 4
Total: USD 88.00

Propargyl-PEG1-bromide

  • CAS No. 18668-74-1

  • Cat. No. CS-0254419
  • Purity≥98%
  • MDL No.MFCD00099299

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG1-bromide|CS-0254419

Structure of 18668-74-1

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General Information

  • CAS No. 18668-74-1
  • Cat. No. CS-0254419
  • Purity ≥98%
  • MDL No. MFCD00099299
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇BrO
  • Molecular Weight 163.01
  • Synonym(s) None
  • SMILES C#CCOCCBr

Description

3-(2-Bromoethoxy)prop-1-yne features a reactive terminal alkyne paired with a bromoethoxy handle, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC). This bifunctional architecture supports rapid conjugation in bioorthogonal labeling and polymer functionalization. The molecule exhibits high stability under standard bench conditions and facilitates site-specific modification in complex media.

Application

3-(2-Bromoethoxy)prop-1-yne serves as a versatile building block for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling efficient access to triazole-containing scaffolds. The terminal alkyne functionality facilitates reliable click chemistry under mild conditions, while the pendant bromoethoxy group provides orthogonal reactivity for further functionalization via nucleophilic substitution. Its bench-stable nature and compatibility with diverse reaction environments make it well-suited for modular synthesis in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Dupuy, Claude; Surzur, Jean-Marie Bulletin de la Societe Chimique de France, 1980 , vol. 2, # 7-8 p. 353 - 360
  • Route2
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    • In-stock
      Propargyl-PEG1-bromide|CS-0254419
      18668-74-1

    References

    • Cresson,P. Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1965 , vol. 261, p. 1707 - 1709
  • Route3

    References

    • Breitenfeld, Jan; Ruiz, Jesus; Wodrich, Matthew D.; Hu, Xile Journal of the American Chemical Society, 2013 , vol. 135, # 32 p. 12004 - 12012

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.0311
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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