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CS-W001157 4
Total: USD 88.00

Methyl 6-chloronicotinate

  • CAS No. 73781-91-6

  • Cat. No. CS-W004062
  • Purity≥98%
  • MDL No.MFCD00023420

*For research and further manufacturing use only, not for direct human use.

Methyl 6-chloronicotinate|CS-W004062

Structure of 73781-91-6

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General Information

  • CAS No. 73781-91-6
  • Cat. No. CS-W004062
  • Purity ≥98%
  • MDL No. MFCD00023420
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) Methyl 6-chloropyridine-3-carboxylate
  • SMILES COC(=O)c1ccc(nc1)Cl

Application

Methyl 6-chloronicotinate serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and pharmaceutical intermediates. Its ortho-chloro substituent provides a site for palladium-catalyzed cross-coupling reactions, while the ester group allows for selective reduction or hydrolysis. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      6-Chloronicotinic acid|CS-D1204
      5326-23-8
    • ~%
    • In-stock
      Methyl 6-chloronicotinate|CS-W004062
      73781-91-6

    References

    • WO2004/63191 A1, ; Page 96 ;
  • Route2

    References

    • US5693611 A1, ;
  • Route3
    • In-stock
      6-Chloronicotinic acid|CS-D1204
      5326-23-8
    • null|null
      74-88-4
    • ~%
    • In-stock
      Methyl 6-chloronicotinate|CS-W004062
      73781-91-6

    References

    • EP1452525 A1, ; Page 14 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H319
Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.5216
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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