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CS-W001157 4
Total: USD 88.00

Methyl 2,6-dichloronicotinate

  • CAS No. 65515-28-8

  • Cat. No. CS-W005384
  • Purity≥98%
  • MDL No.MFCD07369794

*For research and further manufacturing use only, not for direct human use.

Methyl 2,6-dichloronicotinate|CS-W005384

Structure of 65515-28-8

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General Information

  • CAS No. 65515-28-8
  • Cat. No. CS-W005384
  • Purity ≥98%
  • MDL No. MFCD07369794
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅Cl₂NO₂
  • Molecular Weight 206.03
  • Synonym(s) Methyl 2,6-Dichloropyridine-3-carboxylate
  • SMILES O=C(OC)C1=C(Cl)N=C(Cl)C=C1

Description

Methyl 2,6-dichloronicotinate is a bench-stable, electron-deficient heterocyclic ester featuring two chlorine substituents at the 2- and 6-positions of the nicotinate ring. This configuration enhances electrophilicity at the carbonyl carbon, enabling efficient coupling reactions in synthetic pathways. The molecule integrates readily into pharmaceutical intermediates and functional materials where halogenated pyridine motifs are required.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      2,6-Dichloronicotinic acid|CS-W002323
      38496-18-3
    • ~97%
    • In-stock
      Methyl 2,6-dichloronicotinate|CS-W005384
      65515-28-8

    References

    • XENON PHARMACEUTICALS INC. Patent: WO2006/14168 A1, 2006 ; Location in patent: Page/Page column 47 ; WO 2006/014168 A1
  • Route2
    • In-stock
      2,6-Dichloronicotinic acid|CS-W002323
      38496-18-3
    • null|null
      77-78-1
    • ~87%
    • In-stock
      Methyl 2,6-dichloronicotinate|CS-W005384
      65515-28-8

    References

    • Eisai RandD Management Co., Ltd. Patent: EP2062901 A1, 2009 ; Location in patent: Page/Page column 2 ;
  • Route3

    References

    • US4089960 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.175
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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