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CS-W001157 4
Total: USD 88.00

(R)-1-(2-Fluorophenyl)ethan-1-amine

  • CAS No. 185545-90-8

  • Cat. No. CS-0000328
  • Purity≥97%
  • MDL No.MFCD03092993

*For research and further manufacturing use only, not for direct human use.

(R)-1-(2-Fluorophenyl)ethan-1-amine|CS-0000328

Structure of 185545-90-8

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General Information

  • CAS No. 185545-90-8
  • Cat. No. CS-0000328
  • Purity ≥97%
  • MDL No. MFCD03092993
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀FN
  • Molecular Weight 139.17
  • Synonym(s) Benzenemethanamine,2-fluoro-a-methyl-, (aR)-
  • SMILES FC1=C(C=CC=C1)[C@@H](C)N

Description

(R)-1-(2-Fluorophenyl)ethan-1-amine is a chiral amine featuring a fluorinated aromatic ring and a stereogenic center. This bench-stable, moisture-tolerant building block integrates readily into asymmetric synthesis workflows. The para-fluoro substitution enhances metabolic stability while preserving reactivity in transition metal-catalyzed couplings.

Application

(R)-1-(2-Fluorophenyl)ethan-1-amine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of enantiomerically pure pharmaceutical intermediates. Its fluorinated aryl group enhances metabolic stability and modulates electronic properties, while the primary amine facilitates straightforward derivatization via acylation, alkylation, or coupling reactions. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it well-suited for scalable synthesis and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.8454
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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