(S)-1-(2,4-Difluorophenyl)ethan-1-amine

Name: (S)-1-(2,4-Difluorophenyl)ethan-1-amine
Brand: ChemScene
Availability: InStock
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CAS No. 845252-02-0
Cat. No. CS-0000371
Purity≥96%
MDL No.MFCD06761834

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(S)-1-(2,4-Difluorophenyl)ethan-1-amine|CS-0000371

Structure of 845252-02-0

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General Information

CAS No. 845252-02-0
Cat. No. CS-0000371
Purity ≥96%
MDL No. MFCD06761834
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₉F₂N
Molecular Weight 157.16
Synonym(s) ZY1&R BF DF &&S Form
SMILES C[C@@H](C1=C(C=C(C=C1)F)F)N

Description

(S)-1-(2,4-Difluorophenyl)ethan-1-amine is a chiral building block featuring a stereodefined amine group attached to a fluorinated phenyl ring. This configuration imparts enhanced binding specificity in asymmetric synthesis and pharmaceutical development. The molecule exhibits robust stability under standard conditions and integrates seamlessly into diverse synthetic pathways.

Application

(S)-1-(2,4-Difluorophenyl)ethan-1-amine serves as a chiral building block for pharmaceutical intermediates, enabling stereoselective synthesis of bioactive molecules. Its ortho-difluoro substitution enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability, facilitates straightforward purification, and functions effectively in standard amine coupling and reductive amination protocols across diverse synthetic workflows.

Synthesis

Route1
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References
- WO2009/85913 A1, ; Page/Page column 75 ; WO 2009/085913 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 2735
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 26.02
LogP 1.9845
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(S)-1-(2,4-Difluorophenyl)ethan-1-amine

CAS No. 845252-02-0

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