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CS-W001157 4
Total: USD 88.00

1-(2-Fluorophenyl)ethanamine

  • CAS No. 74788-44-6

  • Cat. No. CS-0117041
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(2-Fluorophenyl)ethanamine|CS-0117041

Structure of 74788-44-6

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General Information

  • CAS No. 74788-44-6
  • Cat. No. CS-0117041
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀FN
  • Molecular Weight 139.17
  • Synonym(s) Benzenemethanamine, 2-fluoro-a-methyl-
  • SMILES CC(N)C1=CC=CC=C1F

Description

1-(2-Fluorophenyl)ethanamine features a fluorinated aromatic ring linked to an ethylamine side chain, delivering enhanced metabolic stability and improved membrane permeability. This configuration supports efficient integration into bioactive scaffolds for CNS-targeted therapeutics and synthetic intermediates. The ortho-fluoro substitution imparts directional electronic effects beneficial in transition metal-catalyzed coupling reactions.

Application

1-(2-Fluorophenyl)ethanamine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard amine functionalization. Its fluorinated aryl group enhances metabolic stability and modulates electronic properties, while the primary amine facilitates conjugation reactions. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.8454
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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