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(S)-1-(2-Fluorophenyl)ethylamine hydrochloride

  • CAS No. 1332832-14-0

  • Cat. No. CS-0031394
  • Purity≥97%
  • MDL No.MFCD11865389

*For research and further manufacturing use only, not for direct human use.

(S)-1-(2-Fluorophenyl)ethylamine hydrochloride|CS-0031394

Structure of 1332832-14-0

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General Information

  • CAS No. 1332832-14-0
  • Cat. No. CS-0031394
  • Purity ≥97%
  • MDL No. MFCD11865389
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁ClFN
  • Molecular Weight 175.63
  • Synonym(s) (S)-1-(2-Fluorophenyl)ethanamine hydrochloride
  • SMILES C[C@@H](C1=CC=CC=C1F)N.[H]Cl

Description

(S)-1-(2-Fluorophenyl)ethylamine hydrochloride is a chiral amine featuring a fluorinated phenyl ring and a stereodefined ethylamine side chain. This bench-stable derivative facilitates enantioselective synthesis in pharmaceutical intermediates and asymmetric catalysis, offering enhanced reactivity in transition-metal-mediated transformations due to the electron-withdrawing fluorine substituent.

Application

(S)-1-(2-Fluorophenyl)ethylamine hydrochloride serves as a chiral building block for asymmetric synthesis, offering high enantiomeric purity and stability under standard bench conditions. Its fluorinated aromatic moiety enhances metabolic stability and modulates electronic properties, facilitating incorporation into bioactive scaffolds. The hydrochloride salt form ensures excellent solubility in polar solvents and simplifies handling and purification, making it well-suited for peptide coupling, transition metal-catalyzed transformations, and the construction of pharmaceutical intermediates requiring defined stereochemistry.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.2672
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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