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CS-W001157 4
Total: USD 88.00

VPhos

  • CAS No. 1848244-75-6

  • Cat. No. CS-0035239
  • Purity≥97%
  • MDL No.MFCD30184625

*For research and further manufacturing use only, not for direct human use.

VPhos|CS-0035239

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General Information

  • CAS No. 1848244-75-6
  • Cat. No. CS-0035239
  • Purity ≥97%
  • MDL No. MFCD30184625
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₃H₄₉OP
  • Molecular Weight 492.72
  • Synonym(s) phosphino-2'-methoxy-4',6'-di-t-butyL
  • SMILES CC(C)(C)C(C=C(C(C)(C)C)C=C1OC)=C1C2=C(P(C3CCCCC3)C4CCCCC4)C=CC=C2

Application

VPhos serves as a robust, bench-stable phosphine ligand enabling efficient cross-coupling reactions in palladium-catalyzed processes. Its steric and electronic properties facilitate reliable C–C and C–heteroatom bond formation under mild conditions. The ligand exhibits excellent functional group tolerance and simplifies purification due to low catalyst loading requirements, making it well-suited for scalable synthesis and high-throughput screening applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   9.7298
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   5

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