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CS-W001157 4
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1-tert-Butyl 4-methyl 5,6-dihydropyridine-1,4(2H)-dicarboxylate

  • CAS No. 184368-74-9

  • Cat. No. CS-0041596
  • Purity≥97%
  • MDL No.MFCD23704701

*For research and further manufacturing use only, not for direct human use.

1-tert-Butyl 4-methyl 5,6-dihydropyridine-1,4(2H)-dicarboxylate|CS-0041596

Structure of 184368-74-9

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General Information

  • CAS No. 184368-74-9
  • Cat. No. CS-0041596
  • Purity ≥97%
  • MDL No. MFCD23704701
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₉NO₄
  • Molecular Weight 241.28
  • Synonym(s) None
  • SMILES O=C(N1CCC(C(OC)=O)=CC1)OC(C)(C)C

Description

1-tert-Butyl 4-methyl 5,6-dihydropyridine-1,4(2H)-dicarboxylate features a bench-stable dihydropyridine core with orthogonal ester and methyl functionalities. This scaffold integrates readily into heterocyclic synthesis, offering controlled reactivity for late-stage functionalization in medicinal chemistry and materials development.

Application

1-tert-Butyl 4-methyl 5,6-dihydropyridine-1,4(2H)-dicarboxylate serves as a versatile dihydropyridine building block for the synthesis of functionalized pyridine derivatives. Its protected dihydropyridine core enables controlled oxidation to pyridine scaffolds and participates reliably in transition-metal-catalyzed coupling reactions. The tert-butyl and methyl substituents enhance bench stability and facilitate purification, while the dicarboxylate functionality supports orthogonal derivatization in complex molecule assembly.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.84
  • LogP   1.7266
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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