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CS-W001157 4
Total: USD 88.00

2-(1-(tert-Butoxycarbonyl)azetidin-3-yl)acetic acid

  • CAS No. 183062-96-6

  • Cat. No. CS-W002896
  • Purity≥97%
  • MDL No.MFCD02179028

*For research and further manufacturing use only, not for direct human use.

2-(1-(tert-Butoxycarbonyl)azetidin-3-yl)acetic acid|CS-W002896

Structure of 183062-96-6

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General Information

  • CAS No. 183062-96-6
  • Cat. No. CS-W002896
  • Purity ≥97%
  • MDL No. MFCD02179028
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₇NO₄
  • Molecular Weight 215.25
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CC(CC(=O)O)C1

Description

This azetidine-based acetic acid derivative features a tert-butoxycarbonyl-protected amine, enabling straightforward functionalization in peptide synthesis. The strained azetidinyl ring imparts enhanced reactivity and metabolic stability, while the carboxylic acid group facilitates conjugation or derivatization under standard conditions.

Application

2-(1-(tert-Butoxycarbonyl)azetidin-3-yl)acetic acid serves as a versatile building block for the synthesis of bioactive azetidine-containing compounds. The tert-butoxycarbonyl (Boc) group provides stable protection of the amine, enabling orthogonal manipulation in multi-step sequences. The acetic acid side chain facilitates conjugation via amide bond formation or further functionalization, while the strained azetidine ring imparts unique conformational rigidity. This compound exhibits excellent bench stability and compatibility with standard purification techniques, making it well-suited for medicinal chemistry campaigns targeting kinase inhibitors, CNS agents, and other therapeutically relevant scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.328
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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