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tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate

  • CAS No. 152537-03-6

  • Cat. No. CS-0028392
  • Purity≥95%
  • MDL No.MFCD10699280

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate|CS-0028392

Structure of 152537-03-6

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General Information

  • CAS No. 152537-03-6
  • Cat. No. CS-0028392
  • Purity ≥95%
  • MDL No. MFCD10699280
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₃
  • Molecular Weight 201.27
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CC(C1)CCO

Description

tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate features a strained azetidine core functionalized with a hydroxyl-bearing ethyl side chain, enabling direct incorporation into bioactive scaffolds. The tert-butyl ester group provides stability and facilitates orthogonal deprotection under mild acidic conditions. This compound serves as a key building block in the synthesis of conformationally constrained amines for medicinal chemistry applications.

Application

tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate serves as a versatile building block for the synthesis of bioactive azetidine-containing scaffolds. The molecule combines a stable tert-butyl carbamate protecting group with a pendant hydroxyl functionality, enabling orthogonal derivatization. It facilitates efficient ring expansion and functionalization in medicinal chemistry campaigns, particularly in the construction of heterocyclic cores via nucleophilic substitution or cyclization reactions. Its bench-stable nature and compatibility with standard purification methods make it well-suited for scalable applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.2357
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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