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CS-W001157 4
Total: USD 88.00

benzo[d]oxazol-5-ol

  • CAS No. 180716-28-3

  • Cat. No. CS-W000045
  • Purity≥96%
  • MDL No.MFCD11110248

*For research and further manufacturing use only, not for direct human use.

benzo[d]oxazol-5-ol|CS-W000045

Structure of 180716-28-3

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General Information

  • CAS No. 180716-28-3
  • Cat. No. CS-W000045
  • Purity ≥96%
  • MDL No. MFCD11110248
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅NO₂
  • Molecular Weight 135.12
  • Synonym(s) 5-BENZOXAZOLOL
  • SMILES Oc1ccc2ocnc2c1

Description

Benzo[d]oxazol-5-ol features a fused benzene-oxazole scaffold with a phenolic hydroxyl group at the 5-position, conferring enhanced solubility and hydrogen-bonding capacity. This structural motif enables direct incorporation into bioactive molecules and functional materials, offering stability under standard conditions and utility in pharmaceutical intermediates and fluorescent probes.

Application

Benzo[d]oxazol-5-ol serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its phenolic hydroxyl group facilitates direct functionalization or derivatization, while the fused oxazole ring imparts metabolic stability and favorable binding interactions. The compound exhibits bench stability, ease of handling, and compatibility with standard coupling reactions, making it a practical choice for lead optimization and library synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.26
  • LogP   1.5334
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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