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CS-W001157 4
Total: USD 88.00

2,4-Dichloroquinoline

  • CAS No. 703-61-7

  • Cat. No. CS-D0244
  • Purity≥97%
  • MDL No.MFCD00023939

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloroquinoline|CS-D0244

Structure of 703-61-7

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General Information

  • CAS No. 703-61-7
  • Cat. No. CS-D0244
  • Purity ≥97%
  • MDL No. MFCD00023939
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅Cl₂N
  • Molecular Weight 198.05
  • Synonym(s) quinoline, 2,4-dichloro-
  • SMILES ClC1=CC(Cl)=NC2=CC=CC=C21

Description

Azadibenzocyclooctyne amine is a carbonyl reactive reagent used to incorporate ADIBO into organic compounds, surfaces or particlesAzadibenzocyclooctyne amine is widely useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. It reacts with azide functionalized compounds or bimolecules to give stable triazole linkage without a need for a Cu(I) catalyst.

Application

2,4-Dichloroquinoline serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at both chlorine sites. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of complex heterocyclic architectures, including kinase inhibitors and organic semiconductors.

Synthesis

  • Route1
    • null|null
      70254-43-2
    • ~66%
    • In-stock
      2,4-Dichloroquinoline|CS-D0244
      703-61-7

    References

    • Cheng, Pi; Gu, Qiong; Liu, Wei; Zou, Jian-Feng; Ou, Yang-Yong; Luo, Zhong-Yong; Zeng, Jian-Guo Molecules, 2011 , vol. 16, # 9 p. 7649 - 7661
  • Route2
    • null|null
      141-82-2
    • null|null
      74497-02-2
    • ~68%
    • In-stock
      2,4-Dichloroquinoline|CS-D0244
      703-61-7

    References

    • XTL BIOPHARMACEUTICALS LTD. Patent: WO2008/24423 A2, 2008 ; Location in patent: Page/Page column 35 ;
  • Route3

    References

    • Taisho Pharmaceutical Co. Ltd.; Arena Pharmaceuticals, Inc. Patent: EP1464335 A2, 2004 ; Location in patent: Page/Page column 162 ; EP 1464335 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.5416
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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