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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-iodopyrimidine

  • CAS No. 1806392-49-3

  • Cat. No. CS-0654710
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-iodopyrimidine|CS-0654710

Structure of 1806392-49-3

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General Information

  • CAS No. 1806392-49-3
  • Cat. No. CS-0654710
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂FIN₂
  • Molecular Weight 223.97
  • Synonym(s) None
  • SMILES C1=CN=C(N=C1I)F

Description

2-Fluoro-4-iodopyrimidine serves as a key heterocyclic building block for medicinal chemistry and agrochemical synthesis. This electron-deficient pyrimidine features orthogonal functional handles enabling selective cross-coupling reactions. The fluorine atom enhances metabolic stability, while the iodine moiety facilitates palladium-catalyzed transformations under mild conditions.

Application

2-Fluoro-4-iodopyrimidine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal reactivity profile. The fluorine and iodine substituents allow sequential functionalization, with the C–F bond offering stability under standard reaction conditions while the C–I bond facilitates efficient coupling. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing heterocyclic scaffolds and drug-like molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.2203
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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