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CS-W001157 4
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Oxazol-4-ylmethanol

  • CAS No. 155742-48-6

  • Cat. No. CS-0037571
  • Molecule weight99.09
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Oxazol-4-ylmethanol|CS-0037571

Structure of 155742-48-6

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General Information

  • CAS No. 155742-48-6
  • Cat. No. CS-0037571
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅NO₂
  • Molecular Weight 99.09
  • Synonym(s) 4-Oxazolemethanol
  • SMILES C(C1=COC=N1)O

Description

Oxazol-4-ylmethanol delivers a functionalized heterocyclic scaffold for synthetic applications, featuring a reactive hydroxymethyl group flanked by an oxazole ring. This bench-stable, moisture-tolerant compound integrates readily into complex molecular architectures, enabling efficient coupling and derivatization in medicinal chemistry and materials science workflows.

Application

Oxazol-4-ylmethanol serves as a versatile building block in medicinal chemistry, enabling efficient access to heterocyclic scaffolds through its reactive aldehyde functionality. The molecule exhibits good bench stability and compatibility with common protecting group strategies, facilitating its use in multi-step syntheses. It functions effectively in coupling reactions, nucleophilic additions, and transformations involving oxidation or reduction, making it a practical choice for constructing complex molecules in API development workflows.

Synthesis

  • Route1

    References

    • Chittari, Pabba; Hamada, Yasumasa; Shioiri, Takayuki Synlett, 1998 , # 9 p. 1022 - 1024
  • Route2

    References

    • Ladduwahetty; Baker; Cascieri; Chambers; Haworth; Keown; MacIntyre; Metzger; Owen; Rycroft; Sadowski; Seward; Shepheard; Swain; Tattersall; Watt; Williamson; Hargreaves Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2907 - 2914
  • Route3
    • In-stock
      Ethyl 2-chlorooxazole-4-carboxylate|CS-W004930
      460081-18-9
    • ~0%
    • In-stock
      Oxazol-4-ylmethanol|CS-0037571
      155742-48-6
    • (2-Chlorooxazol-4-yl)methanol|CS-0054868
      706789-06-2

    References

    • Young, Gail L.; Smith, Stephen A.; Taylor, Richard J.K. Tetrahedron Letters, 2004 , vol. 45, # 19 p. 3797 - 3801

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.26
  • LogP   0.1669
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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