2-Fluoropyrimidine

Name: 2-Fluoropyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 31575-35-6
Cat. No. CS-W018601
Purity≥98%
MDL No.MFCD08059530

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 31575-35-6

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General Information

CAS No. 31575-35-6
Cat. No. CS-W018601
Purity ≥98%
MDL No. MFCD08059530
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₃FN₂
Molecular Weight 98.08
Synonym(s) Pyrimidine, 2-fluoro- (8CI,9CI)
SMILES FC1=NC=CC=N1

Description

2-Fluoropyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, offering enhanced metabolic stability and improved binding affinity in kinase inhibitors. This electron-deficient pyrimidine derivative integrates readily into bioactive molecules, enabling efficient coupling reactions under standard conditions.

Application

2-Fluoropyrimidine serves as a versatile building block in medicinal chemistry, enabling site-specific functionalization via nucleophilic aromatic substitution. Its high reactivity at C5 facilitates efficient coupling with diverse amines and thiols, offering reliable access to substituted pyrimidine scaffolds. The fluorine atom enhances metabolic stability and modulates electronic properties, making it valuable for drug discovery. Bench-stable and readily purified, it functions effectively in standard synthetic workflows.

Synthesis

Route1
- In-stock
  
  109-12-6
- ~55%
- In-stock
  
  31575-35-6
References
- Yoneda; Fukuhara Tetrahedron, 1996 , vol. 52, # 1 p. 23 - 36
Route2
- In-stock
  
  1722-12-9
- ~94%
- In-stock
  
  31575-35-6
References
- Fukuhara, Tsuyoshi; Yoneda, Norihiko Chemistry Letters, 1993 , # 3 p. 509 - 512

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS05
Signal Word : Danger	UN#: 1325
Class : 4.1	Packing Group : Ⅲ
Hazard Statements : H226-H302-H315-H318-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

TPSA 25.78
LogP 0.6157
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Fluoropyrimidine

CAS No. 31575-35-6

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