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CS-W001157 4
Total: USD 88.00

2-Aminopyrimidine

  • CAS No. 109-12-6

  • Cat. No. CS-W020110
  • Purity≥96%
  • MDL No.MFCD00006089

*For research and further manufacturing use only, not for direct human use.

2-Aminopyrimidine|CS-W020110

Structure of 109-12-6

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General Information

  • CAS No. 109-12-6
  • Cat. No. CS-W020110
  • Purity ≥96%
  • MDL No. MFCD00006089
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅N₃
  • Molecular Weight 95.11
  • Synonym(s) None
  • SMILES NC1=NC=CC=N1

Description

COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU [1,2].It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated [3]. Associated Protocols and Technical ArticlesGuide to Selection of Coupling ReagentsLiterature references[1] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404. [2] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6. [3] Jean-dAmour, et al. (2011) Org. Lett., 13, 2988.

Synthesis

  • Route1

    References

    • BASF Aktiengesellschaft Patent: US3974159 A1, 1976 ;
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 62, p. 2002,2003 Journal of the American Chemical Society, , vol. 64, p. 567,568
  • Route3

    References

    • EP1607381 A1, ; Page/Page column 8 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.0588
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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