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CS-W001157 4
Total: USD 88.00

2-Hydrazinylpyrimidine

  • CAS No. 7504-94-1

  • Cat. No. CS-W005381
  • Purity≥95%
  • MDL No.MFCD01249337

*For research and further manufacturing use only, not for direct human use.

2-Hydrazinylpyrimidine|CS-W005381

Structure of 7504-94-1

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General Information

  • CAS No. 7504-94-1
  • Cat. No. CS-W005381
  • Purity ≥95%
  • MDL No. MFCD01249337
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆N₄
  • Molecular Weight 110.12
  • Synonym(s) 2-Hydrazinopyrimidine
  • SMILES NNC1=NC=CC=N1

Description

2-Hydrazinylpyrimidine delivers a reactive hydrazino handle for targeted conjugation in medicinal chemistry. This bench-stable heterocycle integrates readily into drug discovery scaffolds, enabling efficient formation of triazoles, imines, and other nitrogen-rich architectures under standard conditions.

Application

2-Hydrazinylpyrimidine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based heterocycles through condensation and cyclization reactions. Its hydrazine functionality facilitates efficient formation of triazoles, imidazoles, and fused polycyclic scaffolds under mild conditions. The compound exhibits good bench stability and compatibility with common functional groups, supporting straightforward purification and integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • Srinivasan, Veeraraghavan; Jebaratnam, David J.; Budil, David E. Journal of Organic Chemistry, 1999 , vol. 64, # 15 p. 5644 - 5649
  • Route2
    • In-stock
      2-Chloropyrimidine|CS-W008600
      1722-12-9
    • null|null
      7727-37-9
    • ~81%
    • In-stock
      2-Hydrazinylpyrimidine|CS-W005381
      7504-94-1

    References

    • ELI LILLY AND COMPANY Patent: WO2008/141020 A1, 2008 ; Location in patent: Page/Page column 58 ; WO 2008/141020 A1
  • Route3

    References

    • Journal of the Chemical Society, , p. 3478,3481

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.83
  • LogP   -0.2378
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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