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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-iodonicotinic acid

  • CAS No. 884494-51-3

  • Cat. No. CS-0041297
  • Purity≥97%
  • MDL No.MFCD03095310

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-iodonicotinic acid|CS-0041297

Structure of 884494-51-3

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General Information

  • CAS No. 884494-51-3
  • Cat. No. CS-0041297
  • Purity ≥97%
  • MDL No. MFCD03095310
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃FINO₂
  • Molecular Weight 267.00
  • Synonym(s) 2-Fluoro-4-iodopyridine-3-carboxylic acid, 3-Carboxy-2-fluoro-4-iodopyridine
  • SMILES FC1=C(C(=O)O)C(=CC=N1)I

Description

2-Fluoro-4-iodonicotinic acid is a halogenated pyridine derivative featuring complementary fluorine and iodine substituents at ortho and para positions, respectively. This combination enables selective cross-coupling transformations in medicinal chemistry applications. The carboxylic acid group facilitates direct derivatization and incorporation into bioactive scaffolds. Bench-stable and moisture-tolerant, it streamlines synthetic access to functionalized heterocycles under standard conditions.

Application

2-Fluoro-4-iodonicotinic acid serves as a versatile building block for transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted nicotinates. The ortho-fluoro and meta-iodo groups offer complementary reactivity for sequential functionalization, with the carboxylic acid facilitating direct derivatization or salt formation. Bench-stable and compatible with standard purification protocols, it supports scalable synthesis of heterocyclic scaffolds relevant to medicinal chemistry and agrochemical research.

Synthesis

  • Route1

    References

    • Amgen Inc. Patent: WO2006/116713 A1, 2006 ; Location in patent: Page/Page column 194-195 ; WO 2006/116713 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5235
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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