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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-iodopyridine-3-carbaldehyde

  • CAS No. 153034-82-3

  • Cat. No. CS-W019830
  • Purity≥98%
  • MDL No.MFCD03095290

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-iodopyridine-3-carbaldehyde|CS-W019830

Structure of 153034-82-3

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General Information

  • CAS No. 153034-82-3
  • Cat. No. CS-W019830
  • Purity ≥98%
  • MDL No. MFCD03095290
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃FINO
  • Molecular Weight 251.00
  • Synonym(s) 4-IODO-2-FLUORO-3-FORMYLPYRIDINE
  • SMILES O=CC1=C(I)C=CN=C1F

Description

2-Fluoro-4-iodopyridine-3-carbaldehyde features a strategically positioned aldehyde group flanked by fluorine and iodine substituents on a pyridine core. This configuration enables direct functionalization in cross-coupling and cyclization reactions, offering high reactivity under standard conditions. The molecule exhibits excellent stability and solubility in common organic solvents, facilitating seamless integration into synthetic workflows for pharmaceutical intermediates and advanced materials.

Application

2-Fluoro-4-iodopyridine-3-carbaldehyde serves as a versatile building block for constructing fluorinated heterocyclic scaffolds in medicinal chemistry. The aldehyde functionality enables direct coupling reactions, while the iodine and fluorine substituents support palladium-catalyzed cross-coupling transformations. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex target molecules.

Synthesis

  • Route1
    • In-stock
      2-Fluoro-3-iodopyridine|CS-D0937
      113975-22-7
    • null|null
      109-94-4
    • ~73%
    • In-stock
      2-Fluoro-4-iodopyridine-3-carbaldehyde|CS-W019830
      153034-82-3

    References

    • Rocca, P.; Cochennec, C.; Marsais, F.; Thomas-dit-Dumont, L.; Mallet, M.; et al. Journal of Organic Chemistry, 1993 , vol. 58, # 27 p. 7832 - 7838

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.6378
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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