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2-(4-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperazin-1-yl)acetic acid

  • CAS No. 180576-05-0

  • Cat. No. CS-0128685
  • Purity≥95%
  • MDL No.MFCD00270202

*For research and further manufacturing use only, not for direct human use.

2-(4-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperazin-1-yl)acetic acid|CS-0128685

Structure of 180576-05-0

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General Information

  • CAS No. 180576-05-0
  • Cat. No. CS-0128685
  • Purity ≥95%
  • MDL No. MFCD00270202
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₂N₂O₄
  • Molecular Weight 366.42
  • Synonym(s) None
  • SMILES O=C(O)CN1CCN(C(=O)OCC2C=3C=CC=CC3C=4C=CC=CC42)CC1

Description

This fluorenylmethoxycarbonyl-protected piperazinylacetic acid derivative serves as a key building block for peptide synthesis and bioconjugation. The Cbz-like fluorenylmethoxy carbonyl group enables selective protection of amine functionalities, while the piperazinyl scaffold imparts solubility and versatility in coupling reactions under standard conditions.

Application

2-(4-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperazin-1-yl)acetic acid serves as a robust, bench-stable building block for peptide and peptidomimetic synthesis. Its fluorenylmethoxycarbonyl (Fmoc)-protected piperazine moiety enables orthogonal functionalization and efficient incorporation into complex scaffolds. The acetic acid handle facilitates conjugation via amide bond formation, while the Fmoc group ensures high compatibility with standard solid-phase peptide synthesis protocols and simplifies purification through its distinctive UV absorbance.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.08
  • LogP   2.6377
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   4

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