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CS-W001157 4
Total: USD 88.00

2-(Piperazin-1-yl)acetic acid

  • CAS No. 37478-58-3

  • Cat. No. CS-0072501
  • Purity≥97%
  • MDL No.MFCD03119773

*For research and further manufacturing use only, not for direct human use.

2-(Piperazin-1-yl)acetic acid|CS-0072501

Structure of 37478-58-3

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General Information

  • CAS No. 37478-58-3
  • Cat. No. CS-0072501
  • Purity ≥97%
  • MDL No. MFCD03119773
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂N₂O₂
  • Molecular Weight 144.17
  • Synonym(s) None
  • SMILES O=C(O)CN1CCNCC1

Description

2-(Piperazin-1-yl)acetic acid features a piperazine ring linked to a carboxylic acid-bearing acetyl side chain, delivering enhanced solubility and hydrogen-bonding capacity. This structural motif enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry scaffolds requiring polar, basic nitrogen centers for target engagement and improved pharmacokinetic profiles.

Application

2-(Piperazin-1-yl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and peptide conjugates. Its pendant piperazine moiety offers enhanced solubility and hydrogen-bonding capacity, while the carboxylic acid group facilitates straightforward coupling reactions. The compound exhibits good bench stability and is compatible with standard purification techniques, making it a practical choice for library synthesis and lead optimization workflows.

Synthesis

  • Route1
    • null|null
      110-85-0
    • null|null
      79-08-3
    • ~%
    • In-stock
      2-(Piperazin-1-yl)acetic acid|CS-0072501
      37478-58-3

    References

    • Apple Corporation Patent: US2004/220412 A1, 2004 ; Location in patent: Page 24 ;
  • Route2
    • In-stock
      Ethyl piperazine-1-carboxylate|CS-W013283
      120-43-4
    • null|null
      79-08-3
    • ~%
    • In-stock
      2-(Piperazin-1-yl)acetic acid|CS-0072501
      37478-58-3

    References

    • Foye; Fedor Journal of the American Pharmaceutical Association (1912-1977), 1959 , vol. 48, p. 412

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.57
  • LogP   -1.0238
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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