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CS-W001157 4
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3-Fluoro-2-methyl-6-nitropyridine

  • CAS No. 1805069-44-6

  • Cat. No. CS-0188196
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-2-methyl-6-nitropyridine|CS-0188196

Structure of 1805069-44-6

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General Information

  • CAS No. 1805069-44-6
  • Cat. No. CS-0188196
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FN₂O₂
  • Molecular Weight 156.11
  • Synonym(s) None
  • SMILES [O-][N+](C1=CC=C(F)C(C)=N1)=O

Description

3-Fluoro-2-methyl-6-nitropyridine features a strategically positioned fluorine atom and electron-deficient nitro group, enabling selective functionalization in cross-coupling reactions. The methyl substituent enhances regiocontrol, while the pyridine core provides robust stability under standard conditions. This compound serves as a key building block for bioactive heterocycles and advanced pharmaceutical intermediates.

Application

3-Fluoro-2-methyl-6-nitropyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling. The ortho-fluoro and nitro groups facilitate selective C–H activation and nucleophilic substitution, while the methyl group provides steric and electronic modulation. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthesis of heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.43732
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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